sparsentan will lessen the extent or effect of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor. Sparsentan (a CYP2C19 inducer) decreases publicity of CYP2C19 substrates and reduces efficacy related to these substrates.No unique dose adjustment advised when tofacitinib coadministered with powerful CYP2C19 inhibitors; de
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